InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPP1

Summary

InnateDB Gene

IDBG-29322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPP1

Gene Name

secreted phosphoprotein 1

Synonyms

BNSP; BSPI; ETA-1; OPN

Species

Homo sapiens

Ensembl Gene

ENSG00000118785

Encoded Proteins

IDBP-29324

secreted phosphoprotein 1

IDBP-29326

secreted phosphoprotein 1

IDBP-240243

secreted phosphoprotein 1

IDBP-485095

secreted phosphoprotein 1

IDBP-809620

secreted phosphoprotein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21136203

SPP1 exist in secreted and intracellular form; intracellular SPP1, or iSPP1, is involved in cytoskeleton rearrangement and signal transduction downstream of innate immunity receptors (e.g. TLR). iSPP1 may also function as an adaptor or scaffolding protein.

InnateDB Annotation from Orthologs

Summary

PMID 21136203

[Mus musculus] Spp1 exist in secreted and intracellular form; intracellular Spp1, or iSpp1, is involved in cytoskeleton rearrangement and signal transduction downstream of innate immunity receptors (e.g. TLR). iSPP1 may also function as an adaptor or scaffolding protein.

Entrez Gene

Summary

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:87975650-87983426

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000237623	ENSP00000237623
ENST00000360804	ENSP00000354042
ENST00000395080	ENSP00000378517
ENST00000504310
ENST00000513981
ENST00000509334
ENST00000508233	ENSP00000422973
ENST00000509659
ENST00000508002
ENST00000505146
ENST00000614857	ENSP00000477824

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007566	embryo implantation
GO:0010033	response to organic substance
GO:0010811	positive regulation of cell-substrate adhesion
GO:0022617	extracellular matrix disassembly
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0031214	biomineral tissue development
GO:0033280	response to vitamin D
GO:0045087	innate immune response (InnateDB)
GO:0045780	positive regulation of bone resorption
GO:0046697	decidualization
GO:0048545	response to steroid hormone
GO:0048685	negative regulation of collateral sprouting of intact axon in response to injury

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031988	membrane-bounded vesicle
GO:0042995	cell projection
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome