Homo sapiens Gene: UQCRB | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-29384.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | UQCRB | ||||||||||||||||||||||
Gene Name | ubiquinol-cytochrome c reductase binding protein | ||||||||||||||||||||||
Synonyms | MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6; UQPC | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000156467 | ||||||||||||||||||||||
Encoded Proteins |
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase binding protein
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 8:96225920-96235634 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q22.1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Respiratory electron transport pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
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KEGG |
Alzheimer's disease pathway
Oxidative phosphorylation pathway
Parkinson's disease pathway
Huntington's disease pathway
Cardiac muscle contraction pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | B7Z2R2 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 7381 | ||||||||||||||||||||||
UniGene | Hs.404298 Hs.663220 | ||||||||||||||||||||||
RefSeq | NM_001199975 NM_001254752 NM_006294 XM_006716652 | ||||||||||||||||||||||
HUGO | HGNC:12582 | ||||||||||||||||||||||
OMIM | 191330 | ||||||||||||||||||||||
CCDS | CCDS59107 CCDS6269 | ||||||||||||||||||||||
HPRD | 11770 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK295007 AP003465 | ||||||||||||||||||||||
GenPept | BAH11948 | ||||||||||||||||||||||
RNA Seq Atlas | 102725189 7381 | ||||||||||||||||||||||