Version 5.4
Homo sapiens Gene: HERC6
Summary
InnateDB Gene IDBG-29637.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HERC6
Gene Name HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138642
Encoded Proteins
IDBP-29639
hect domain and RLD 6
IDBP-29643
hect domain and RLD 6
IDBP-29645
hect domain and RLD 6
IDBP-477151
hect domain and RLD 6
IDBP-484557
hect domain and RLD 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:88378739-88443111
Strand Forward strand
Band q22.1
Transcripts
ENST00000380265 ENSP00000369617
ENST00000264346 ENSP00000264346
ENST00000273960 ENSP00000273960
ENST00000504905 ENSP00000425504
ENST00000506714
ENST00000502870 ENSP00000425060
ENST00000515365
ENST00000506842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029798
View Gene Order
ENSBTAG00000020536
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.529317
RefSeq NM_001165136 NM_017912 XM_005263083
HUGO
OMIM
CCDS CCDS47098 CCDS54777
HPRD 13647
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca