InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ROCK2

Summary

InnateDB Gene

IDBG-29657.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROCK2

Gene Name

Rho-associated, coiled-coil containing protein kinase 2

Synonyms

ROCK-II

Species

Homo sapiens

Ensembl Gene

ENSG00000134318

Encoded Proteins

IDBP-1373

Rho-associated, coiled-coil containing protein kinase 2

IDBP-29659

Rho-associated, coiled-coil containing protein kinase 2

IDBP-292790

Rho-associated, coiled-coil containing protein kinase 2

IDBP-363918

Rho-associated, coiled-coil containing protein kinase 2

IDBP-812540

Rho-associated, coiled-coil containing protein kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:11179761-11348330

Strand

Reverse strand

Band

p25.1

Transcripts

ENST00000261535	ENSP00000261535
ENST00000315872	ENSP00000317985
ENST00000401753	ENSP00000385509
ENST00000431087	ENSP00000395957
ENST00000493096
ENST00000460262
ENST00000484951
ENST00000462366
ENST00000616279	ENSP00000481789

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000910	cytokinesis
GO:0001843	neural tube closure
GO:0006468	protein phosphorylation
GO:0006939	smooth muscle contraction
GO:0007411	axon guidance
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010825	positive regulation of centrosome duplication
GO:0016525	negative regulation of angiogenesis
GO:0030036	actin cytoskeleton organization
GO:0030155	regulation of cell adhesion
GO:0032956	regulation of actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0042752	regulation of circadian rhythm
GO:0045616	regulation of keratinocyte differentiation
GO:0048511	rhythmic process
GO:0051298	centrosome duplication
GO:0051492	regulation of stress fiber assembly
GO:0051893	regulation of focal adhesion assembly
GO:2000114	regulation of establishment of cell polarity
GO:2000145	regulation of cell motility

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031616	spindle pole centrosome
GO:0036464	cytoplasmic ribonucleoprotein granule