Version 5.4
Homo sapiens Gene: E2F6
Summary
InnateDB Gene IDBG-29751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2F6
Gene Name E2F transcription factor 6
Synonyms E2F-6
Species Homo sapiens
Ensembl Gene ENSG00000169016
Encoded Proteins
IDBP-29753
E2F transcription factor 6
IDBP-29757
E2F transcription factor 6
IDBP-364015
E2F transcription factor 6
IDBP-364018
E2F transcription factor 6
IDBP-364022
E2F transcription factor 6
IDBP-364025
E2F transcription factor 6
IDBP-364027
E2F transcription factor 6
IDBP-600382
E2F transcription factor 6
IDBP-603465
E2F transcription factor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:11444375-11466177
Strand Reverse strand
Band p25.1
Transcripts
ENST00000381525 ENSP00000370936
ENST00000307236 ENSP00000302159
ENST00000444832 ENSP00000413678
ENST00000428221 ENSP00000407650
ENST00000455198 ENSP00000403449
ENST00000437573 ENSP00000406891
ENST00000421117 ENSP00000389113
ENST00000471343
ENST00000468775
ENST00000498701
ENST00000542100 ENSP00000446315
ENST00000546212 ENSP00000438864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
Biological Process
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0071339 MLL1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057469
View Gene Order
ENSBTAG00000048286
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt O75461
TrEMBL Q53YM3 Q6Q9Z5
UniProt Splice Variant
Entrez Gene 1876
UniGene Hs.635564 Hs.638824 Hs.708518
RefSeq NM_001278278 NM_001278275 NM_001278276 NM_001278277 NM_198256 NM_212540 XM_005246155
HUGO HGNC:3120
OMIM 602944
CCDS CCDS62858 CCDS1680 CCDS62859
HPRD 04251
IMGT
EMBL AC099344 AF041381 AF059292 AJ493061 AK096197 AK290413 AY083996 AY083997 AY551347 AY551348 AY551349 AY551350 AY551351 BC008348 BC107740 CH471053
GenPept AAC14694 AAC31426 AAH08348 AAI07741 AAM10783 AAM10784 AAM10785 AAT02637 AAT02638 AAT02639 AAT02640 AAT02641 AAY14826 BAF83102 BAG53228 CAD37950 EAX00931 EAX00934 EAX00935 EAX00936
RNA Seq Atlas 1876

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca