Homo sapiens Gene: IDH2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-29824.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | IDH2 | ||||||||||||||||||
Gene Name | isocitrate dehydrogenase 2 (NADP+), mitochondrial | ||||||||||||||||||
Synonyms | D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000182054 | ||||||||||||||||||
Encoded Proteins |
isocitrate dehydrogenase 2 (NADP+), mitochondrial
isocitrate dehydrogenase 2 (NADP+), mitochondrial
isocitrate dehydrogenase 2 (NADP+), mitochondrial
isocitrate dehydrogenase 2 (NADP+), mitochondrial
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq, Jul 2008] Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 15:90083045-90102504 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q26.1 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Citric acid cycle (TCA cycle) pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
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KEGG |
Citrate cycle (TCA cycle) pathway
Glutathione metabolism pathway
Peroxisome pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | B4DFL2 B4DSZ6 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 3418 | ||||||||||||||||||
UniGene | Hs.596461 Hs.737985 | ||||||||||||||||||
RefSeq | NM_001289910 NM_001290114 NM_002168 | ||||||||||||||||||
HUGO | HGNC:5383 | ||||||||||||||||||
OMIM | 147650 | ||||||||||||||||||
CCDS | CCDS10359 | ||||||||||||||||||
HPRD | 00973 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC087284 AC092769 AK294148 AK299987 AK316388 | ||||||||||||||||||
GenPept | BAG57473 BAG61808 BAH14759 | ||||||||||||||||||
RNA Seq Atlas | 3418 | ||||||||||||||||||