InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCR9

Summary

InnateDB Gene

IDBG-29830.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR9

Gene Name

chemokine (C-C motif) receptor 9

Synonyms

CC-CKR-9; CDw199; GPR-9-6; GPR28

Species

Homo sapiens

Ensembl Gene

ENSG00000173585

Encoded Proteins

IDBP-29832

chemokine (C-C motif) receptor 9

IDBP-29834

chemokine (C-C motif) receptor 9

IDBP-238486

chemokine (C-C motif) receptor 9

IDBP-374406

chemokine (C-C motif) receptor 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:45886504-45903177

Strand

Forward strand

Band

p21.31

Transcripts

ENST00000357632	ENSP00000350256
ENST00000355983	ENSP00000348260
ENST00000395963	ENSP00000379292
ENST00000422395	ENSP00000393267
ENST00000463197

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029530

View Gene Order

ENSBTAG00000031348

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

hsa04672

Intestinal immune network for IgA production pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

C9JWC0

UniProt Splice Variant

Entrez Gene

10803

UniGene

Hs.225946 Hs.671587

RefSeq

NM_001256369 NM_006641 NM_031200

HUGO

HGNC:1610

OMIM

604738

CCDS

CCDS2732 CCDS2733

HPRD

09200

IMGT

EMBL

AC099782

GenPept

RNA Seq Atlas

10803