Version 5.4
Homo sapiens Gene: HERC3
Summary
InnateDB Gene IDBG-29858.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HERC3
Gene Name HECT and RLD domain containing E3 ubiquitin protein ligase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138641
Encoded Proteins
IDBP-29860
hect domain and RLD 3
IDBP-293044
hect domain and RLD 3
IDBP-293037
hect domain and RLD 3
IDBP-374300
hect domain and RLD 3
IDBP-374304
hect domain and RLD 3
IDBP-374307
hect domain and RLD 3
IDBP-374308
hect domain and RLD 3
IDBP-474964
hect domain and RLD 3
IDBP-479262
hect domain and RLD 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:88521048-88708542
Strand Forward strand
Band q22.1
Transcripts
ENST00000264345 ENSP00000264345
ENST00000402738 ENSP00000385684
ENST00000407637 ENSP00000384005
ENST00000431413 ENSP00000405863
ENST00000422770 ENSP00000410029
ENST00000426683 ENSP00000389991
ENST00000452979 ENSP00000406210
ENST00000513325 ENSP00000424786
ENST00000470815
ENST00000504994
ENST00000512194 ENSP00000421021
ENST00000601319
ENST00000597259
ENST00000598772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
Biological Process
GO:0016567 protein ubiquitination
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029804
View Gene Order
ENSBTAG00000010120
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9J6Z1 C9J8E7 C9JFL2 C9JKA7 D6RAT5
UniProt Splice Variant
Entrez Gene 8916
UniGene Hs.35804 Hs.595977 Hs.623770 Hs.734064
RefSeq NM_001271602 NM_014606 XM_005263327 XM_005263328 XM_005263329
HUGO HGNC:4876
OMIM 605200
CCDS CCDS34028
HPRD 16093
IMGT
EMBL AC083829 AC098582 AC108065
GenPept
RNA Seq Atlas 101929134 8916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca