Version 5.4
Homo sapiens Gene: POP1
Summary
InnateDB Gene IDBG-29914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POP1
Gene Name processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104356
Encoded Proteins
IDBP-29916
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
IDBP-295665
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
IDBP-475336
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:98117297-98159834
Strand Forward strand
Band q22.2
Transcripts
ENST00000349693 ENSP00000339529
ENST00000401707 ENSP00000385787
ENST00000522319 ENSP00000428945
ENST00000517435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000171 ribonuclease MRP activity
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001682 tRNA 5'-leader removal
GO:0006396 RNA processing
GO:0016078 tRNA catabolic process
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0000172 ribonuclease MRP complex
GO:0005615 extracellular space
GO:0005655 nucleolar ribonuclease P complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022325
View Gene Order
ENSBTAG00000012596
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.252828
RefSeq NM_001145860 NM_001145861 NM_015029
HUGO
OMIM
CCDS CCDS6277
HPRD 03923
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca