InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE8B

Summary

InnateDB Gene

IDBG-30033.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE8B

Gene Name

phosphodiesterase 8B

Synonyms

ADSD; PPNAD3

Species

Homo sapiens

Ensembl Gene

ENSG00000113231

Encoded Proteins

IDBP-30037

phosphodiesterase 8B

IDBP-30039

phosphodiesterase 8B

IDBP-30041

phosphodiesterase 8B

IDBP-30043

phosphodiesterase 8B

IDBP-30045

phosphodiesterase 8B

IDBP-477353

phosphodiesterase 8B

IDBP-482455

phosphodiesterase 8B

IDBP-482188

phosphodiesterase 8B

IDBP-479354

phosphodiesterase 8B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:77210449-77429807

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000264917	ENSP00000264917
ENST00000342343	ENSP00000345646
ENST00000340978	ENSP00000345446
ENST00000333194	ENSP00000331336
ENST00000346042	ENSP00000330428
ENST00000505926	ENSP00000425720
ENST00000502945	ENSP00000426200
ENST00000503963	ENSP00000422861
ENST00000505283	ENSP00000423461

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000156	two-component response regulator activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006198	cAMP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0009187	cyclic nucleotide metabolic process
GO:0035556	intracellular signal transduction
GO:0046676	negative regulation of insulin secretion
GO:0090032	negative regulation of steroid hormone biosynthetic process

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021684

View Gene Order

ENSBTAG00000020205

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.584830 Hs.598523 Hs.739571

RefSeq

NM_001029851 NM_001029852 NM_001029853 NM_001029854 NM_003719 XM_005248621 XM_005248623 XM_005248624

HUGO

OMIM

CCDS

CCDS34190 CCDS34191 CCDS34192 CCDS34193 CCDS4037

HPRD

04546

IMGT

EMBL

GenPept

RNA Seq Atlas