Version 5.4
Homo sapiens Gene: SIAH1
Summary
InnateDB Gene IDBG-30112.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIAH1
Gene Name siah E3 ubiquitin protein ligase 1
Synonyms SIAH1A
Species Homo sapiens
Ensembl Gene ENSG00000196470
Encoded Proteins
IDBP-30114
seven in absentia homolog 1 (Drosophila)
IDBP-30116
seven in absentia homolog 1 (Drosophila)
IDBP-240998
seven in absentia homolog 1 (Drosophila)
IDBP-752664
IDBP-747943
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 11742346
SIAH1 is a ubiquitin ligase structurally related to TRAF and modulates TNF-alpha signalling.
Entrez Gene
Summary This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson\'s disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:48356364-48448402
Strand Reverse strand
Band q12.1
Transcripts
ENST00000380006 ENSP00000369343
ENST00000356721 ENSP00000349156
ENST00000394725 ENSP00000378214
ENST00000568007 ENSP00000456421
ENST00000573005
ENST00000565620
ENST00000567973
ENST00000563745 ENSP00000457415
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 125 [view]
Protein-Protein 124 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0009653 anatomical structure morphogenesis
GO:0030163 protein catabolic process
GO:0031648 protein destabilization
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0051402 neuron apoptotic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030877 beta-catenin destruction complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036840
View Gene Order
ENSBTAG00000010868
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q8IUQ4
TrEMBL H3BU09
UniProt Splice Variant
Entrez Gene 6477
UniGene Hs.730684 Hs.732204 Hs.734460 Hs.743277
RefSeq NM_001006610 NM_003031
HUGO HGNC:10857
OMIM 602212
CCDS CCDS10735 CCDS32444
HPRD
IMGT
EMBL AC023818 AC026470 AJ400626 BC035562 BC042550 BC044920 BX647064 EF026094 U63295 U76247
GenPept AAC12950 AAC51907 AAH35562 AAH42550 AAH44920 ABK15529 CAC35542 CAE46191
RNA Seq Atlas 6477

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca