InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PIAS2

Summary

InnateDB Gene

IDBG-3013.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIAS2

Gene Name

protein inhibitor of activated STAT, 2

Synonyms

ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4

Species

Homo sapiens

Ensembl Gene

ENSG00000078043

Encoded Proteins

IDBP-3017

protein inhibitor of activated STAT, 2

IDBP-232525

protein inhibitor of activated STAT, 2

IDBP-586082

protein inhibitor of activated STAT, 2

IDBP-726301

IDBP-727133

IDBP-726422

IDBP-807933

protein inhibitor of activated STAT, 2

IDBP-726938

IDBP-725589

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 12764129

Functions as an E3 ligase to promote STAT1 SUMO modification

Entrez Gene

Summary

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:46808390-46920160

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000324794	ENSP00000317163
ENST00000398654	ENSP00000381648
ENST00000545673	ENSP00000443238
ENST00000586170
ENST00000592221	ENSP00000466596
ENST00000586953	ENSP00000468166
ENST00000589917	ENSP00000465312
ENST00000592212	ENSP00000479025
ENST00000589819
ENST00000590127
ENST00000587810	ENSP00000468017
ENST00000585916	ENSP00000465676
ENST00000586634
ENST00000592011
ENST00000590944
ENST00000591865

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	97 [view]
Protein-Protein	95 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0050681	androgen receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008152	metabolic process
GO:0016925	protein sumoylation
GO:0030521	androgen receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045667	regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060766	negative regulation of androgen receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0016604	nuclear body
GO:0016605	PML body
GO:0016607	nuclear speck

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025423

View Gene Order

ENSBTAG00000007833

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

hsa05222

Small cell lung cancer pathway

hsa04630

Jak-STAT signaling pathway pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

il12_stat4pathway

IL12 signaling mediated by STAT4

ranbp2pathway

Sumoylation by RanBP2 regulates transcriptional repression

Cross-References

SwissProt

O75928

TrEMBL

A0A024RC49 B4DGW0 K7EJT4 K7EMP6 K7EQX5 K7ER97

UniProt Splice Variant

Entrez Gene

9063

UniGene

Hs.595787 Hs.618029 Hs.634224 Hs.735219 Hs.739149

RefSeq

NM_004671 NM_173206 XM_005258377 XM_005258379 XM_005258381 XM_005258382 XM_005258383 XM_006722571 XM_006722572 XM_006722573

HUGO

HGNC:17311

OMIM

603567

CCDS

CCDS32824 CCDS32825

HPRD

IMGT

EMBL

AC090241 AC090373 AF077953 AF077954 AF361054 AK294801 BC015190 CH471088

GenPept

AAC36704 AAC36705 AAH15190 AAK48938 BAG57921 EAX01484 EAX01486

RNA Seq Atlas

9063