Version 5.4
Homo sapiens Gene: SMARCAD1
Summary
InnateDB Gene IDBG-30360.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMARCAD1
Gene Name SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163104
Encoded Proteins
IDBP-30362
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
IDBP-30364
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
IDBP-240509
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
IDBP-374495
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
IDBP-481228
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
IDBP-478618
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:94207611-94291292
Strand Forward strand
Band q22.3
Transcripts
ENST00000359052 ENSP00000351947
ENST00000354268 ENSP00000346217
ENST00000394961 ENSP00000378413
ENST00000457823 ENSP00000415576
ENST00000510105 ENSP00000424624
ENST00000509418 ENSP00000423286
ENST00000506089
ENST00000514232
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
Experimentally validated
Total 124 [view]
Protein-Protein 124 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0000729 DNA double-strand break processing
GO:0006338 chromatin remodeling
GO:0009117 nucleotide metabolic process
GO:0016568 chromatin modification
GO:0043044 ATP-dependent chromatin remodeling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051260 protein homooligomerization
GO:0051304 chromosome separation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0016363 nuclear matrix
GO:0035861 site of double-strand break
GO:0043596 nuclear replication fork
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029920
View Gene Order
ENSBTAG00000017061
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.410406
RefSeq NM_001128429 NM_001128430 NM_001254949 NM_020159 XM_006714275 XM_006714276
HUGO
OMIM
CCDS CCDS3639 CCDS47101 CCDS58914
HPRD 11586
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca