Version 5.4
Homo sapiens Gene: EIF3F
Summary
InnateDB Gene IDBG-30424.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3F
Gene Name eukaryotic translation initiation factor 3, subunit F
Synonyms eIF3-p47; EIF3S5
Species Homo sapiens
Ensembl Gene ENSG00000175390
Encoded Proteins
IDBP-30426
eukaryotic translation initiation factor 3, subunit F
IDBP-596109
eukaryotic translation initiation factor 3, subunit F
IDBP-596411
eukaryotic translation initiation factor 3, subunit F
IDBP-584236
eukaryotic translation initiation factor 3, subunit F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:7970251-8001862
Strand Forward strand
Band p15.4
Transcripts
ENST00000309828 ENSP00000310040
ENST00000533626 ENSP00000431800
ENST00000531329 ENSP00000432489
ENST00000528653
ENST00000532882
ENST00000530219
ENST00000528763
ENST00000531572 ENSP00000434286
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 112 [view]
Protein-Protein 112 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0006508 proteolysis
GO:0010467 gene expression
GO:0016579 protein deubiquitination
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031029
View Gene Order
ENSBTAG00000004861
Not yet available
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445442 Hs.516023 Hs.603548 Hs.685978 Hs.739257
RefSeq NM_003754
HUGO
OMIM
CCDS CCDS7785
HPRD 04887
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca