Version 5.4
Homo sapiens Gene: MYH2
Summary
InnateDB Gene IDBG-30433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYH2
Gene Name myosin, heavy chain 2, skeletal muscle, adult
Synonyms IBM3; MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2
Species Homo sapiens
Ensembl Gene ENSG00000125414
Encoded Proteins
IDBP-30435
myosin, heavy chain 2, skeletal muscle, adult
IDBP-235883
myosin, heavy chain 2, skeletal muscle, adult
IDBP-368611
myosin, heavy chain 2, skeletal muscle, adult
IDBP-587121
myosin, heavy chain 2, skeletal muscle, adult
IDBP-763148
IDBP-811302
myosin, heavy chain 2, skeletal muscle, adult
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:10521148-10549957
Strand Reverse strand
Band p13.1
Transcripts
ENST00000245503 ENSP00000245503
ENST00000397183 ENSP00000380367
ENST00000420805 ENSP00000399348
ENST00000532183 ENSP00000433944
ENST00000578017 ENSP00000463668
ENST00000622564 ENSP00000482463
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003735 structural constituent of ribosome
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
Biological Process
GO:0001778 plasma membrane repair
GO:0006412 translation
GO:0006936 muscle contraction
GO:0008152 metabolic process
GO:0014823 response to activity
GO:0016192 vesicle-mediated transport
GO:0030049 muscle filament sliding
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0061024 membrane organization
GO:0070252 actin-mediated cell contraction
Cellular Component
GO:0005622 intracellular
GO:0005794 Golgi apparatus
GO:0005826 actomyosin contractile ring
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005859 muscle myosin complex
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0016459 myosin complex
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0031672 A band
GO:0032982 myosin filament
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033196
View Gene Order
ENSBTAG00000007090
Not yet available
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt Q9UKX2
TrEMBL E7EX84 J3QLR0 Q567P6
UniProt Splice Variant
Entrez Gene 4620
UniGene Hs.667534
RefSeq NM_001100112 NM_017534
HUGO HGNC:7572
OMIM 160740
CCDS CCDS11156
HPRD
IMGT
EMBL AC005323 AF111784 BC093082 BC126409 BX510904 S73840 Z32858
GenPept AAC13916 AAD29950 AAH93082 AAI26410 CAA83687 CAD91136
RNA Seq Atlas 4620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca