InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADCY7

Summary

InnateDB Gene

IDBG-30450.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCY7

Gene Name

adenylate cyclase 7

Synonyms

AC7

Species

Homo sapiens

Ensembl Gene

ENSG00000121281

Encoded Proteins

IDBP-30452

adenylate cyclase 7

IDBP-241046

adenylate cyclase 7

IDBP-584206

adenylate cyclase 7

IDBP-749420

IDBP-750414

IDBP-744911

IDBP-746954

IDBP-751751

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. [provided by RefSeq, Jul 2008]
This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:50246137-50318135

Strand

Forward strand

Band

q12.1

Transcripts

ENST00000254235	ENSP00000254235
ENST00000394697	ENSP00000378187
ENST00000537579	ENSP00000437788
ENST00000568930
ENST00000567277	ENSP00000455670
ENST00000568933
ENST00000566761	ENSP00000454301
ENST00000562623
ENST00000570187
ENST00000564965	ENSP00000460636
ENST00000566433	ENSP00000457409
ENST00000563677
ENST00000569265	ENSP00000460018
ENST00000568731
ENST00000564044

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004016	adenylate cyclase activity
GO:0005524	ATP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0046872	metal ion binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006171	cAMP biosynthetic process
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007268	synaptic transmission
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009190	cyclic nucleotide biosynthetic process
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0034199	activation of protein kinase A activity
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0055085	transmembrane transport
GO:0060135	maternal process involved in female pregnancy
GO:0071361	cellular response to ethanol
GO:0071377	cellular response to glucagon stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031659

View Gene Order

ENSBTAG00000006208

Not yet available

Pathways

NETPATH

REACTOME

REACT_15530

PKA activation pathway

REACT_15497

PKA-mediated phosphorylation of CREB pathway

REACT_9000

Calmodulin induced events pathway

REACT_9053

CaM pathway pathway

REACT_111064

DAG and IP3 signaling pathway

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_24023

Vasopressin regulates renal water homeostasis via Aquaporins pathway

REACT_12079

PLC-gamma1 signalling pathway

REACT_12478

EGFR interacts with phospholipase C-gamma pathway

REACT_9417

Signaling by EGFR pathway

REACT_19231

G alpha (i) signalling events pathway

REACT_19327

G alpha (s) signalling events pathway

REACT_19333

G alpha (z) signalling events pathway

REACT_15312

Adenylate cyclase activating pathway pathway

REACT_15333

Adenylate cyclase inhibitory pathway pathway

REACT_15426

PLC beta mediated events pathway

REACT_15295

Opioid Signalling pathway

REACT_115720

PLCG1 events in ERBB2 signaling pathway

REACT_115755

Signaling by ERBB2 pathway

REACT_21310

Phospholipase C-mediated cascade pathway

REACT_9470

Signaling by FGFR pathway

REACT_17025

Downstream signal transduction pathway

REACT_16888

Signaling by PDGF pathway

REACT_25031

GABA B receptor activation pathway

REACT_1946

PKA activation in glucagon signalling pathway

REACT_1665

Glucagon signaling in metabolic regulation pathway

REACT_1505

Integration of energy metabolism pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_11061

Signalling by NGF pathway

REACT_228134

Signaling by Hedgehog pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_21272

Downstream signaling of activated FGFR pathway

REACT_13685

Neuronal System pathway

REACT_14797

Signaling by GPCR pathway

REACT_6802

Innate Immune System pathway

REACT_25199

GABA receptor activation pathway

REACT_25330

Activation of GABAB receptors pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_267634

Hedgehog 'off' state pathway

REACT_15526

G-protein mediated events pathway

REACT_6900

Immune System pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_111217

Metabolism pathway

REACT_25282

Inhibition of adenylate cyclase pathway pathway

REACT_15307

Ca-dependent events pathway

REACT_23887

Aquaporin-mediated transport pathway

REACT_116125

Disease pathway

KEGG

hsa04912

GnRH signaling pathway pathway

hsa04540

Gap junction pathway

hsa00230

Purine metabolism pathway

hsa04020

Calcium signaling pathway pathway

hsa04916

Melanogenesis pathway

hsa04270

Vascular smooth muscle contraction pathway

hsa04062

Chemokine signaling pathway pathway

hsa04914

Progesterone-mediated oocyte maturation pathway

hsa05414

Dilated cardiomyopathy pathway

hsa04114

Oocyte meiosis pathway

hsa04971

Gastric acid secretion pathway

hsa04972

Pancreatic secretion pathway

hsa04970

Salivary secretion pathway

hsa04976

Bile secretion pathway

INOH

INOH website

GPCR Adenosine A2A receptor signaling pathway pathway

INOH website

Purine nucleotides nucleosides metabolism pathway

INOH website

GPCR signaling pathway

PID NCI

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.708878

RefSeq

NM_001114 NM_001286057 XM_005255779 XM_005255780 XM_005255781 XM_005255782 XM_005255783 XM_005255784 XM_005255785 XM_005255786 XM_006721128

HUGO

OMIM

CCDS

CCDS10741 CCDS73882

HPRD

02663

IMGT

EMBL

GenPept

RNA Seq Atlas