Version 5.4
Homo sapiens Gene: MCM7
Summary
InnateDB Gene IDBG-30522.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM7
Gene Name minichromosome maintenance complex component 7
Synonyms CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104
Species Homo sapiens
Ensembl Gene ENSG00000166508
Encoded Proteins
IDBP-30526
minichromosome maintenance complex component 7
IDBP-30528
minichromosome maintenance complex component 7
IDBP-30530
minichromosome maintenance complex component 7
IDBP-383148
minichromosome maintenance complex component 7
IDBP-596376
minichromosome maintenance complex component 7
IDBP-813752
minichromosome maintenance complex component 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100092728-100101940
Strand Reverse strand
Band q22.1
Transcripts
ENST00000303887 ENSP00000307288
ENST00000343023 ENSP00000344006
ENST00000354230 ENSP00000346171
ENST00000425308 ENSP00000411295
ENST00000489841
ENST00000485286
ENST00000491245 ENSP00000445904
ENST00000493352
ENST00000477372
ENST00000463722
ENST00000467516
ENST00000465688
ENST00000465738
ENST00000621318 ENSP00000483795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 188 [view]
Protein-Protein 185 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016851 magnesium chelatase activity
GO:0016887 ATPase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 cellular response to DNA damage stimulus
GO:0008283 cell proliferation
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process
GO:0042325 regulation of phosphorylation
GO:0042493 response to drug
GO:0071310 cellular response to organic substance
GO:0071364 cellular response to epidermal growth factor stimulus
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0042555 MCM complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029730
View Gene Order
ENSBTAG00000030965
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_6776
Unwinding of DNA pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_829
Regulation of DNA replication pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa03030
DNA replication pathway
hsa04110
Cell cycle pathway
INOH
PID NCI
atr_pathway
ATR signaling pathway
Cross-References
SwissProt P33993
TrEMBL C9J8M6
UniProt Splice Variant
Entrez Gene 4176
UniGene Hs.438720
RefSeq NM_001278595 NM_005916 NM_182776
HUGO HGNC:6950
OMIM 600592
CCDS CCDS5683 CCDS5684
HPRD 01154
IMGT
EMBL AC073842 AK055379 BC009398 BC013375 CH236956 CH471091 D28480 D55716 X74796
GenPept AAH09398 AAH13375 BAA05839 BAA09534 BAG51508 CAA52803 EAL23855 EAL23856 EAW76598 EAW76599
RNA Seq Atlas 4176

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca