InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAN2B1

Summary

InnateDB Gene

IDBG-30534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAN2B1

Gene Name

mannosidase, alpha, class 2B, member 1

Synonyms

LAMAN; MANB

Species

Homo sapiens

Ensembl Gene

ENSG00000104774

Encoded Proteins

IDBP-30536

mannosidase, alpha, class 2B, member 1

IDBP-372872

mannosidase, alpha, class 2B, member 1

IDBP-764979

IDBP-760590

IDBP-761068

IDBP-766005

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:12646511-12666742

Strand

Reverse strand

Band

p13.13

Transcripts

ENST00000221363	ENSP00000221363
ENST00000456935	ENSP00000395473
ENST00000433513
ENST00000469423
ENST00000480851
ENST00000493218
ENST00000466794
ENST00000495617
ENST00000465830
ENST00000462144
ENST00000486847	ENSP00000470174
ENST00000596512
ENST00000593686	ENSP00000471685
ENST00000596591	ENSP00000469456
ENST00000595880
ENST00000598876	ENSP00000470533
ENST00000600281

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559	alpha-mannosidase activity
GO:0008270	zinc ion binding
GO:0015923	mannosidase activity
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006013	mannose metabolic process
GO:0006464	cellular protein modification process
GO:0006517	protein deglycosylation

Cellular Component

GO:0005764	lysosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005142

View Gene Order

ENSBTAG00000006241

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00511

Other glycan degradation pathway

hsa04142

Lysosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.356769

RefSeq

NM_000528 NM_001173498 XM_005259913

HUGO

OMIM

CCDS

CCDS32919 CCDS54224

HPRD

02007

IMGT

EMBL

GenPept

RNA Seq Atlas