Version 5.4
Homo sapiens Gene: MYH3
Summary
InnateDB Gene IDBG-30560.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYH3
Gene Name myosin, heavy chain 3, skeletal muscle, embryonic
Synonyms HEMHC; MYHC-EMB; MYHSE1; SMHCE
Species Homo sapiens
Ensembl Gene ENSG00000109063
Encoded Proteins
IDBP-760809
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:10628526-10657309
Strand Reverse strand
Band p13.1
Transcripts
ENST00000579489
ENST00000577963
ENST00000579928
ENST00000582580
ENST00000583535 ENSP00000464317
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0042623 ATPase activity, coupled
GO:0051015 actin filament binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006200 ATP catabolic process
GO:0007517 muscle organ development
GO:0030048 actin filament-based movement
GO:0030049 muscle filament sliding
GO:0030326 embryonic limb morphogenesis
GO:0045214 sarcomere organization
GO:0060325 face morphogenesis
Cellular Component
GO:0005829 cytosol
GO:0005859 muscle myosin complex
GO:0016459 myosin complex
GO:0030017 sarcomere
GO:0032982 myosin filament
GO:0043292 contractile fiber
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020908
View Gene Order
ENSBTAG00000011803
Not yet available
Pathways
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt P11055
TrEMBL
UniProt Splice Variant
Entrez Gene 4621
UniGene Hs.440895
RefSeq NM_002470 XM_006721528
HUGO HGNC:7573
OMIM 160720
CCDS CCDS11157
HPRD
IMGT
EMBL AC002347 X13100 X13988 X15696 X51593
GenPept CAA31492 CAA32167 CAA33731 CAA35942
RNA Seq Atlas 4621

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca