Version 5.4
Homo sapiens Gene: SPAG1
Summary
InnateDB Gene IDBG-30594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAG1
Gene Name sperm associated antigen 1
Synonyms CILD28; CT140; HSD-3.8; SP75; TPIS
Species Homo sapiens
Ensembl Gene ENSG00000104450
Encoded Proteins
IDBP-30596
sperm associated antigen 1
IDBP-30600
sperm associated antigen 1
IDBP-477445
sperm associated antigen 1
IDBP-481992
sperm associated antigen 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:100157906-100259278
Strand Forward strand
Band q22.2
Transcripts
ENST00000251809 ENSP00000251809
ENST00000388798 ENSP00000373450
ENST00000520643 ENSP00000427716
ENST00000520508 ENSP00000428070
ENST00000523302
ENST00000519424
ENST00000519409
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
Biological Process
GO:0007338 single fertilization
GO:0008152 metabolic process
GO:0070286 axonemal dynein complex assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037617
View Gene Order
ENSBTAG00000032544
Not yet available
Cross-References
SwissProt Q07617
TrEMBL
UniProt Splice Variant
Entrez Gene 6674
UniGene Hs.591866 Hs.711834
RefSeq NM_003114 NM_172218 XM_006716619
HUGO HGNC:11212
OMIM 603395
CCDS CCDS34930
HPRD 04548
IMGT
EMBL AC025647 AF311312 AK057482 BC055091 CH471060
GenPept AAG23967 AAH55091 BAG51920 EAW91800
RNA Seq Atlas 6674

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca