InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT10B

Summary

InnateDB Gene

IDBG-30678.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT10B

Gene Name

wingless-type MMTV integration site family, member 10B

Synonyms

SHFM6; WNT-12

Species

Homo sapiens

Ensembl Gene

ENSG00000169884

Encoded Proteins

IDBP-30682

wingless-type MMTV integration site family, member 10B

IDBP-293376

wingless-type MMTV integration site family, member 10B

IDBP-293374

wingless-type MMTV integration site family, member 10B

IDBP-374067

wingless-type MMTV integration site family, member 10B

IDBP-374068

wingless-type MMTV integration site family, member 10B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96%% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:48965340-48971763

Strand

Reverse strand

Band

q13.12

Transcripts

ENST00000301061	ENSP00000301061
ENST00000407467	ENSP00000384691
ENST00000403957	ENSP00000385980
ENST00000413630	ENSP00000398473
ENST00000420388	ENSP00000404896
ENST00000475740

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0048018	receptor agonist activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002062	chondrocyte differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006629	lipid metabolic process
GO:0007050	cell cycle arrest
GO:0007224	smoothened signaling pathway
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0014835	myoblast differentiation involved in skeletal muscle regeneration
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030501	positive regulation of bone mineralization
GO:0030858	positive regulation of epithelial cell differentiation
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043403	skeletal muscle tissue regeneration
GO:0045165	cell fate commitment
GO:0045598	regulation of fat cell differentiation
GO:0045599	negative regulation of fat cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045778	positive regulation of ossification
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048641	regulation of skeletal muscle tissue development
GO:0048741	skeletal muscle fiber development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050821	protein stabilization
GO:0050909	sensory perception of taste
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051246	regulation of protein metabolic process
GO:0051885	positive regulation of anagen
GO:0060070	canonical Wnt signaling pathway
GO:0060346	bone trabecula formation
GO:0061196	fungiform papilla development
GO:0071300	cellular response to retinoic acid
GO:0071310	cellular response to organic substance
GO:0071320	cellular response to cAMP
GO:0071374	cellular response to parathyroid hormone stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071425	hematopoietic stem cell proliferation
GO:0071464	cellular response to hydrostatic pressure
GO:0090263	positive regulation of canonical Wnt signaling pathway