InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF6

Summary

InnateDB Gene

IDBG-30683.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF6

Gene Name

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

Synonyms

MGC:8964; TAF(II)70; TAF(II)80; TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85

Species

Homo sapiens

Ensembl Gene

ENSG00000106290

Encoded Proteins

IDBP-30685

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-374722

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-383233

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-383240

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-383241

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-383243

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-383249

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-383251

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-383254

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-383257

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-383259

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-477973

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-474512

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-483611

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-476899

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

IDBP-484150

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:100107070-100119841

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000344095	ENSP00000344537
ENST00000431404	ENSP00000395627
ENST00000421980	ENSP00000413614
ENST00000453269	ENSP00000389575
ENST00000452041	ENSP00000416396
ENST00000437822	ENSP00000399982
ENST00000440225	ENSP00000410012
ENST00000452438	ENSP00000412346
ENST00000449571	ENSP00000390073
ENST00000451699	ENSP00000406315
ENST00000417349	ENSP00000390220
ENST00000472509	ENSP00000419760
ENST00000487115
ENST00000487288
ENST00000493322	ENSP00000419555
ENST00000523306	ENSP00000428639
ENST00000520135	ENSP00000428071
ENST00000460673	ENSP00000427710
ENST00000497233

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	70 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0016032	viral process
GO:0045786	negative regulation of cell cycle
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0005737	cytoplasm
GO:0033276	transcription factor TFTC complex
GO:0071339	MLL1 complex