InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APOC2

Summary

InnateDB Gene

IDBG-306903.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOC2

Gene Name

apolipoprotein C-II

Synonyms

APO-CII; APOC-II

Species

Homo sapiens

Ensembl Gene

ENSG00000234906

Encoded Proteins

IDBP-763990

IDBP-765384

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:44946035-44949565

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000585786	ENSP00000465001
ENST00000590360	ENSP00000466775

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008047	enzyme activator activity
GO:0008289	lipid binding
GO:0016004	phospholipase activator activity
GO:0042803	protein homodimerization activity
GO:0043274	phospholipase binding
GO:0055102	lipase inhibitor activity
GO:0060230	lipoprotein lipase activator activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0006629	lipid metabolic process
GO:0006869	lipid transport
GO:0007603	phototransduction, visible light
GO:0010518	positive regulation of phospholipase activity
GO:0010898	positive regulation of triglyceride catabolic process
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0016042	lipid catabolic process
GO:0032375	negative regulation of cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034370	triglyceride-rich lipoprotein particle remodeling
GO:0034371	chylomicron remodeling
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0034382	chylomicron remnant clearance
GO:0034384	high-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0043085	positive regulation of catalytic activity
GO:0043086	negative regulation of catalytic activity
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0060697	positive regulation of phospholipid catabolic process
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome