Version 5.4
Homo sapiens Gene: RNF19A
Summary
InnateDB Gene IDBG-30691.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF19A
Gene Name ring finger protein 19A, E3 ubiquitin protein ligase
Synonyms RNF19
Species Homo sapiens
Ensembl Gene ENSG00000034677
Encoded Proteins
IDBP-30693
ring finger protein 19A
IDBP-374424
ring finger protein 19A
IDBP-484193
ring finger protein 19A
IDBP-476786
ring finger protein 19A
IDBP-476945
ring finger protein 19A
IDBP-485142
ring finger protein 19A
IDBP-475044
ring finger protein 19A
IDBP-481584
ring finger protein 19A
IDBP-808037
ring finger protein 19A, RBR E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies, a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein binds and ubiquitylates synphilin 1 (SNCAIP) which is an interacting protein of alpha synuclein in neurons and a major component of Lewy bodies. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Feb 2012]
This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson\'s disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:100257059-100410015
Strand Reverse strand
Band q22.2
Transcripts
ENST00000341084 ENSP00000342667
ENST00000432381 ENSP00000397305
ENST00000519449 ENSP00000428968
ENST00000520903
ENST00000523255
ENST00000523644
ENST00000520071
ENST00000524233
ENST00000519527 ENSP00000431077
ENST00000523167 ENSP00000429549
ENST00000522369 ENSP00000429841
ENST00000517584 ENSP00000429161
ENST00000523481 ENSP00000430553
ENST00000522182
ENST00000519342
ENST00000616528 ENSP00000480369
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022280
View Gene Order
ENSBTAG00000017833
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.292882 Hs.689938 Hs.735657
RefSeq NM_001280539 NM_015435 NM_183419 XM_005250853 XM_005250854
HUGO
OMIM
CCDS CCDS6286
HPRD 06176
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca