Version 5.4
Homo sapiens Gene: SPANXB2
Summary
InnateDB Gene IDBG-306993.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPANXB2
Gene Name SPANX family, member B2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000227234
Encoded Proteins
IDBP-381989
SPANX family, member B2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B1 and appears to be a duplication of that locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008] Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:141002591-141003706
Strand Forward strand
Band q27.1
Transcripts
ENST00000449283 ENSP00000405202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007286 spermatid development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9NS25
TrEMBL
UniProt Splice Variant
Entrez Gene 728695
UniGene Hs.434105 Hs.711489
RefSeq NM_032461
HUGO HGNC:14330
OMIM 300669
CCDS CCDS44006
HPRD
IMGT
EMBL AF098307 AJ457789 AJ457793 AJ457796 AL031078 AY787057 AY787058 AY787059 AY787060 AY787061 AY787062 AY787063 AY787064 AY787065 AY787066 AY787067 AY787068 AY787069 AY787070 AY787071 AY787072 AY787073 AY787074 AY787075 AY787076 AY787077 AY787078 AY787079 AY787080 AY787081 AY787082 AY787083 AY787090 AY787092 AY787127 AY787130 AY787632 BC034472 BC137533 BC137536
GenPept AAF28421 AAH34472 AAI37534 AAI37537 AAW47348 AAW47349 AAW47350 AAW47351 AAW47352 AAW47353 AAW47354 AAW47355 AAW47356 AAW47357 AAW47358 AAW47359 AAW47360 AAW47361 AAW47362 AAW47363 AAW47364 AAW47365 AAW47366 AAW47367 AAW47368 AAW47369 AAW47370 AAW47371 AAW47372 AAW47373 AAW47374 AAW47376 AAW47377 AAW47380 AAW47382 AAW47383 CAD29838 CAD29842 CAD29845 CAI42717 CAI42718
RNA Seq Atlas 728695

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca