Version 5.4
Homo sapiens Gene: TOX3
Summary
InnateDB Gene IDBG-30826.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOX3
Gene Name TOX high mobility group box family member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103460
Encoded Proteins
IDBP-30828
TOX high mobility group box family member 3
IDBP-295480
TOX high mobility group box family member 3
IDBP-745474
IDBP-748908
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:52438005-52547802
Strand Reverse strand
Band q12.1
Transcripts
ENST00000219746 ENSP00000219746
ENST00000407228 ENSP00000385705
ENST00000566696
ENST00000568436 ENSP00000463843
ENST00000563091 ENSP00000457401
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0034056 estrogen response element binding
GO:0042803 protein homodimerization activity
GO:0051219 phosphoprotein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043668
View Gene Order
ENSBTAG00000000418
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.460789 Hs.605733
RefSeq NM_001080430 NM_001146188 XM_005255892 XM_005255893
HUGO
OMIM
CCDS CCDS54008 CCDS54009
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca