Version 5.4
Homo sapiens Gene: PABPC1
Summary
InnateDB Gene IDBG-30847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PABPC1
Gene Name poly(A) binding protein, cytoplasmic 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000070756
Encoded Proteins
IDBP-30849
poly(A) binding protein, cytoplasmic 1
IDBP-474397
poly(A) binding protein, cytoplasmic 1
IDBP-473793
poly(A) binding protein, cytoplasmic 1
IDBP-484506
poly(A) binding protein, cytoplasmic 1
IDBP-484099
poly(A) binding protein, cytoplasmic 1
IDBP-479991
poly(A) binding protein, cytoplasmic 1
IDBP-480217
poly(A) binding protein, cytoplasmic 1
IDBP-476075
poly(A) binding protein, cytoplasmic 1
IDBP-479622
poly(A) binding protein, cytoplasmic 1
IDBP-476791
poly(A) binding protein, cytoplasmic 1
IDBP-480719
poly(A) binding protein, cytoplasmic 1
IDBP-483962
poly(A) binding protein, cytoplasmic 1
IDBP-480917
poly(A) binding protein, cytoplasmic 1
IDBP-484213
poly(A) binding protein, cytoplasmic 1
IDBP-481528
poly(A) binding protein, cytoplasmic 1
IDBP-483152
poly(A) binding protein, cytoplasmic 1
IDBP-481729
poly(A) binding protein, cytoplasmic 1
IDBP-482830
poly(A) binding protein, cytoplasmic 1
IDBP-474638
poly(A) binding protein, cytoplasmic 1
IDBP-808041
poly(A) binding protein, cytoplasmic 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:100685816-100722809
Strand Reverse strand
Band q22.3
Transcripts
ENST00000318607 ENSP00000313007
ENST00000518293 ENSP00000430716
ENST00000520868 ENSP00000428021
ENST00000519004 ENSP00000429594
ENST00000522387 ENSP00000429395
ENST00000523636 ENSP00000428948
ENST00000517990 ENSP00000428030
ENST00000522658 ENSP00000428840
ENST00000519848
ENST00000517403 ENSP00000428190
ENST00000519596
ENST00000518716
ENST00000519622 ENSP00000427805
ENST00000519100 ENSP00000427914
ENST00000517921
ENST00000523555 ENSP00000429892
ENST00000518196 ENSP00000430159
ENST00000521865 ENSP00000429119
ENST00000520142 ENSP00000430012
ENST00000522720 ENSP00000429790
ENST00000521067 ENSP00000428937
ENST00000520804 ENSP00000428749
ENST00000519363 ENSP00000429032
ENST00000610907 ENSP00000478108
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 242 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 242 [view]
Protein-Protein 235 [view]
Protein-DNA 2 [view]
Protein-RNA 5 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008143 poly(A) binding
GO:0008266 poly(U) RNA binding
GO:0008494 translation activator activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000398 mRNA splicing, via spliceosome
GO:0006378 mRNA polyadenylation
GO:0006412 translation
GO:0006413 translational initiation
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031047 gene silencing by RNA
GO:0044267 cellular protein metabolic process
GO:0045727 positive regulation of translation
GO:0048255 mRNA stabilization
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022283
View Gene Order
ENSBTAG00000046358
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_25325
AUF1 (hnRNP D0) destabilizes mRNA pathway
REACT_20514
Deadenylation of mRNA pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.387804 Hs.735874
RefSeq NM_002568 XM_005250861
HUGO
OMIM
CCDS CCDS6289
HPRD 05247
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca