InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CEBPE

Summary

InnateDB Gene

IDBG-3098.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEBPE

Gene Name

CCAAT/enhancer binding protein (C/EBP), epsilon

Synonyms

C/EBP-epsilon; CRP1

Species

Homo sapiens

Ensembl Gene

ENSG00000092067

Encoded Proteins

IDBP-3100

CCAAT/enhancer binding protein (C/EBP), epsilon

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21326902

CEBPE is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.

InnateDB Annotation from Orthologs

Summary

PMID 21326902

[Mus musculus] Cebpe is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.

Entrez Gene

Summary

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:23117304-23119616

Strand

Reverse strand

Band

q11.2

Transcripts

ENST00000206513

ENSP00000206513

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	63 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006909	phagocytosis
GO:0006952	defense response
GO:0010628	positive regulation of gene expression
GO:0030099	myeloid cell differentiation
GO:0030225	macrophage differentiation
GO:0042089	cytokine biosynthetic process
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000052435

View Gene Order

ENSBTAG00000005952

Not yet available

Cross-References

SwissProt

Q15744

TrEMBL

UniProt Splice Variant

Entrez Gene

1053

UniGene

Hs.558308

RefSeq

NM_001805

HUGO

HGNC:1836

OMIM

600749

CCDS

CCDS9589

HPRD

IMGT

EMBL

BC035797 U48865 U48866 U80982

GenPept

AAC50708 AAC50709 AAC51130 AAH35797

RNA Seq Atlas

1053