Version 5.4
Homo sapiens Gene: CHD2
Summary
InnateDB Gene IDBG-31108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHD2
Gene Name chromodomain helicase DNA binding protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173575
Encoded Proteins
IDBP-242066
chromodomain helicase DNA binding protein 2
IDBP-380812
chromodomain helicase DNA binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:92900321-93028003
Strand Forward strand
Band q26.1
Transcripts
ENST00000394196 ENSP00000377747
ENST00000420239 ENSP00000406581
ENST00000557682
ENST00000553829
ENST00000556895
ENST00000554669
ENST00000554894
ENST00000557147
ENST00000554133
ENST00000555227
ENST00000555520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005524 ATP binding
GO:0042393 histone binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007517 muscle organ development
GO:0016568 chromatin modification
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078671
View Gene Order
ENSBTAG00000017776
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.220864
RefSeq NM_001271 NM_001042572
HUGO
OMIM
CCDS CCDS10374 CCDS45356
HPRD 03669
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca