Version 5.4
Homo sapiens Gene: PILRA
Summary
InnateDB Gene IDBG-31114.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PILRA
Gene Name paired immunoglobin-like type 2 receptor alpha
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000085514
Encoded Proteins
IDBP-31116
paired immunoglobin-like type 2 receptor alpha
IDBP-31118
paired immunoglobin-like type 2 receptor alpha
IDBP-242489
paired immunoglobin-like type 2 receptor alpha
IDBP-383482
paired immunoglobin-like type 2 receptor alpha
IDBP-383488
paired immunoglobin-like type 2 receptor alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100367530-100400099
Strand Forward strand
Band q22.1
Transcripts
ENST00000198536 ENSP00000198536
ENST00000350573 ENSP00000340109
ENST00000394000 ENSP00000377569
ENST00000432297 ENSP00000415111
ENST00000453419 ENSP00000390026
ENST00000484934
ENST00000474013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0016032 viral process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_21
RANKL pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JGG1 C9JJ79
UniProt Splice Variant
Entrez Gene 29992
UniGene
RefSeq NM_013439 NM_178272 NM_178273 XM_006715954 XM_006715955
HUGO HGNC:20396
OMIM 605341
CCDS CCDS47660 CCDS5691 CCDS5692
HPRD 05631
IMGT
EMBL AC005071
GenPept
RNA Seq Atlas 29992

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca