Version 5.4
Homo sapiens Gene: KLF1
Summary
InnateDB Gene IDBG-31252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF1
Gene Name Kruppel-like factor 1 (erythroid)
Synonyms CDAN4; EKLF; HBFQTL6; INLU
Species Homo sapiens
Ensembl Gene ENSG00000105610
Encoded Proteins
IDBP-31254
Kruppel-like factor 1 (erythroid)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12884423-12887181
Strand Reverse strand
Band p13.13
Transcripts
ENST00000264834 ENSP00000264834
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0030218 erythrocyte differentiation
GO:0035162 embryonic hemopoiesis
GO:0043249 erythrocyte maturation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048821 erythrocyte development
GO:1901653 cellular response to peptide
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054191
View Gene Order
ENSBTAG00000006083
Not yet available
Cross-References
SwissProt Q13351
TrEMBL B9UZC3
UniProt Splice Variant
Entrez Gene 10661
UniGene Hs.37860
RefSeq NM_006563
HUGO HGNC:6345
OMIM 600599
CCDS CCDS12285
HPRD
IMGT
EMBL AD000092 BC033580 FJ200444 U37106 U65404
GenPept AAB51173 AAC50562 AAC51108 AAH33580 ACM18112
RNA Seq Atlas 10661

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca