InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAD23A

Summary

InnateDB Gene

IDBG-31509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD23A

Gene Name

RAD23 homolog A (S. cerevisiae)

Synonyms

HHR23A; HR23A

Species

Homo sapiens

Ensembl Gene

ENSG00000179262

Encoded Proteins

IDBP-31511

RAD23 homolog A (S. cerevisiae)

IDBP-762085

IDBP-762975

IDBP-763662

IDBP-766251

IDBP-765761

IDBP-763875

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23357418

RAD23A is a negative regulator of the RIG-I anti-viral signalling pathway by mediating the ubiquitin-dependent proteasomal degradation of TRAF2.

InnateDB Annotation from Orthologs

Summary

PMID 23357418

[Mus musculus] RAD23A is a negative regulator of the RIG-I anti-viral signalling pathway by mediating the ubiquitin-dependent proteasomal degradation of TRAF2.

Entrez Gene

Summary

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:12945855-12953642

Strand

Forward strand

Band

p13.13

Transcripts

ENST00000316856	ENSP00000321365
ENST00000588826
ENST00000591467
ENST00000590881	ENSP00000467628
ENST00000586534	ENSP00000467024
ENST00000592268	ENSP00000468674
ENST00000588329
ENST00000586375	ENSP00000466226
ENST00000591499	ENSP00000466243
ENST00000593114	ENSP00000466968

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	162 [view]
Protein-Protein	162 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0031593	polyubiquitin binding
GO:1990381	ubiquitin-specific protease binding

Biological Process

GO:0006289	nucleotide-excision repair
GO:0006974	cellular response to DNA damage stimulus
GO:0016032	viral process
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045070	positive regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003813

View Gene Order

ENSBTAG00000015116

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa03420

Nucleotide excision repair pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

5886

UniGene

Hs.643267

RefSeq

NM_001270362 NM_001270363 NM_005053

HUGO

HGNC:9812

OMIM

600061

CCDS

CCDS12289 CCDS59357 CCDS59358

HPRD

07191

IMGT

EMBL

GenPept

RNA Seq Atlas

102723937 5886