Version 5.4
Homo sapiens Gene: BCL2L2
Summary
InnateDB Gene IDBG-3157.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL2L2
Gene Name BCL2-like 2
Synonyms BCL-W; BCL2-L-2; BCLW; PPP1R51
Species Homo sapiens
Ensembl Gene ENSG00000129473
Encoded Proteins
IDBP-3159
BCL2-like 2
IDBP-595414
BCL2-like 2
IDBP-598305
BCL2-like 2
IDBP-599342
BCL2-like 2
IDBP-596804
BCL2-like 2
IDBP-585240
BCL2-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:23298790-23311759
Strand Forward strand
Band q11.2
Transcripts
ENST00000250405 ENSP00000250405
ENST00000553824 ENSP00000451148
ENST00000557236 ENSP00000451701
ENST00000557579 ENSP00000452265
ENST00000554635 ENSP00000451234
ENST00000556599 ENSP00000451197
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051400 BH domain binding
Biological Process
GO:0006915 apoptotic process
GO:0007283 spermatogenesis
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0060011 Sertoli cell proliferation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0031966 mitochondrial membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000089682
View Gene Order
ENSBTAG00000019692
Not yet available
Cross-References
SwissProt
TrEMBL G3V3B7 G3V3G8 G3V5A9
UniProt Splice Variant
Entrez Gene 599
UniGene Hs.410026
RefSeq NM_001199839 NM_004050
HUGO HGNC:995
OMIM 601931
CCDS CCDS9591
HPRD 03569
IMGT
EMBL AL049829
GenPept
RNA Seq Atlas 599

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca