Version 5.4
Homo sapiens Gene: LAMTOR3
Summary
InnateDB Gene IDBG-31575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMTOR3
Gene Name late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Synonyms MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633; Ragulator3
Species Homo sapiens
Ensembl Gene ENSG00000109270
Encoded Proteins
IDBP-31577
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
IDBP-474012
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99878336-99894490
Strand Reverse strand
Band q23
Transcripts
ENST00000226522 ENSP00000226522
ENST00000499666 ENSP00000424183
ENST00000515100
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 80 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0032947 protein complex scaffold
Biological Process
GO:0032006 regulation of TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0034613 cellular protein localization
GO:0043547 positive regulation of GTPase activity
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0070062 extracellular vesicular exosome
GO:0071986 Ragulator complex
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
ENSBTAG00000007923
Not yet available
ENSMUSG00000094685
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9UHA4
TrEMBL
UniProt Splice Variant
Entrez Gene 8649
UniGene Hs.743221
RefSeq NM_001243736 NM_021970
HUGO HGNC:15606
OMIM 603296
CCDS CCDS3652 CCDS58920
HPRD
IMGT
EMBL AF130115 AF201947 AK311755 AL544981 AP001962 BC026245 CH471057
GenPept AAF17239 AAG35540 AAH26245 BAG34698 EAX06112
RNA Seq Atlas 8649

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca