Version 5.4
Homo sapiens Gene: PCOLCE
Summary
InnateDB Gene IDBG-31590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCOLCE
Gene Name procollagen C-endopeptidase enhancer
Synonyms PCPE; PCPE-1; PCPE1
Species Homo sapiens
Ensembl Gene ENSG00000106333
Encoded Proteins
IDBP-31592
procollagen C-endopeptidase enhancer
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100602177-100608175
Strand Forward strand
Band q22.1
Transcripts
ENST00000223061 ENSP00000223061
ENST00000496269
ENST00000462260
ENST00000482863
ENST00000487172
ENST00000468214
ENST00000460002
ENST00000490909
ENST00000486440
ENST00000472348
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008201 heparin binding
GO:0016504 peptidase activator activity
Biological Process
GO:0006508 proteolysis
GO:0007275 multicellular organismal development
GO:0010952 positive regulation of peptidase activity
Cellular Component
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029718
View Gene Order
ENSBTAG00000020528
Not yet available
Pathways
NETPATH
REACTOME
REACT_150206
Crosslinking of collagen fibrils pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_118779
Extracellular matrix organization pathway
REACT_120729
Collagen formation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.202097
RefSeq NM_002593
HUGO
OMIM
CCDS CCDS5700
HPRD 02603
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca