InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DYRK1A

Summary

InnateDB Gene

IDBG-3163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYRK1A

Gene Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

Synonyms

DYRK; DYRK1; HP86; MNB; MNBH; MRD7

Species

Homo sapiens

Ensembl Gene

ENSG00000157540

Encoded Proteins

IDBP-3165

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

IDBP-3167

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

IDBP-231762

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

IDBP-231764

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

IDBP-365576

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

IDBP-365578

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5\' UTR or in the 3\' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:37365790-37517450

Strand

Forward strand

Band

q22.13

Transcripts

ENST00000339659	ENSP00000340373
ENST00000338785	ENSP00000342690
ENST00000398960	ENSP00000381932
ENST00000398956	ENSP00000381929
ENST00000426672	ENSP00000412269
ENST00000455097	ENSP00000398483
ENST00000462274
ENST00000498351
ENST00000608928

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0043621	protein self-association
GO:0048156	tau protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006468	protein phosphorylation
GO:0007399	nervous system development
GO:0007623	circadian rhythm
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	protein autophosphorylation
GO:0090312	positive regulation of protein deacetylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016607	nuclear speck
GO:0030529	ribonucleoprotein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022897

View Gene Order

ENSBTAG00000001771

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_10

Hedgehog pathway

NetPath_11

TCR pathway

REACTOME

REACT_111214

G0 and Early G1 pathway

REACT_21267

Mitotic G1-G1/S phases pathway

REACT_115566

Cell Cycle pathway

REACT_152

Cell Cycle, Mitotic pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.368240 Hs.719974

RefSeq

NM_001396 NM_101395 NM_130436 NM_130438 XM_005260931 XM_005260933 XM_006723976 XM_006723977 XM_006723978 XM_006723979

HUGO

OMIM

CCDS

CCDS13653 CCDS13654 CCDS42925 CCDS42926

HPRD

09018

IMGT

EMBL

GenPept

RNA Seq Atlas