InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: H2AFZ

Summary

InnateDB Gene

IDBG-31707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2AFZ

Gene Name

H2A histone family, member Z

Synonyms

H2A.z; H2A.Z-1; H2A/z; H2AZ

Species

Homo sapiens

Ensembl Gene

ENSG00000164032

Encoded Proteins

IDBP-31709

H2A histone family, member Z

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:99948086-99950388

Strand

Reverse strand

Band

q23

Transcripts

ENST00000296417	ENSP00000296417
ENST00000511348
ENST00000511203
ENST00000511319
ENST00000529158
ENST00000527366

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	62 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0031492	nucleosomal DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006334	nucleosome assembly
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0000786	nucleosome
GO:0005634	nucleus
GO:0005719	nuclear euchromatin
GO:0005720	nuclear heterochromatin

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000037894

View Gene Order

Pathways

NETPATH

REACTOME

REACT_75792

Meiotic synapsis pathway

REACT_22186

Deposition of new CENPA-containing nucleosomes at the centromere pathway

REACT_7963

Packaging Of Telomere Ends pathway

REACT_75925

Amyloids pathway

REACT_2204

RNA Polymerase I Chain Elongation pathway

REACT_2232

RNA Polymerase I Promoter Opening pathway

REACT_27271

Meiotic recombination pathway

REACT_120956

Cellular responses to stress pathway

REACT_200808

PRC2 methylates histones and DNA pathway

REACT_228096

misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway

REACT_1309

RNA Polymerase I Transcription pathway

REACT_228331

Signaling by WNT in cancer pathway

REACT_172744

Condensation of Prophase Chromosomes pathway

REACT_11045

Signaling by Wnt pathway

REACT_22172

Chromosome Maintenance pathway

REACT_22344

Nucleosome assembly pathway

REACT_267668

Transcriptional regulation by small RNAs pathway

REACT_200857

Epigenetic regulation of gene expression pathway

REACT_1974

RNA Polymerase I Promoter Clearance pathway

REACT_200856

NoRC negatively regulates rRNA expression pathway

REACT_7970

Telomere Maintenance pathway

REACT_111102

Signal Transduction pathway

REACT_200827

SIRT1 negatively regulates rRNA Expression pathway

REACT_115566

Cell Cycle pathway

REACT_169185

DNA Damage/Telomere Stress Induced Senescence pathway

REACT_267652

DNA methylation pathway

REACT_910

M Phase pathway

REACT_169274

Cellular Senescence pathway

REACT_200777

TCF dependent signaling in response to WNT pathway

REACT_172623

Chromatin organization pathway

REACT_765

Mitotic Prophase pathway

REACT_228108

RMTs methylate histone arginines pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_152

Cell Cycle, Mitotic pathway

REACT_228188

RNF mutants show enhanced WNT signaling and proliferation pathway

REACT_200753

formation of the beta-catenin:TCF transactivating complex pathway

REACT_21352

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway

REACT_169168

Senescence-Associated Secretory Phenotype (SASP) pathway

REACT_111183

Meiosis pathway

REACT_228279

XAV939 inhibits tankyrase, stabilizing AXIN pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

REACT_200834

Negative epigenetic regulation of rRNA expression pathway

REACT_12472

Regulatory RNA pathways pathway

KEGG

hsa05322

Systemic lupus erythematosus pathway

INOH

PID NCI

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.119192 Hs.625718

RefSeq

NM_002106

HUGO

OMIM

CCDS

CCDS3654

HPRD

00823

IMGT

EMBL

GenPept

RNA Seq Atlas