InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AMFR

Summary

InnateDB Gene

IDBG-31785.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMFR

Gene Name

autocrine motility factor receptor, E3 ubiquitin protein ligase

Synonyms

GP78; RNF45

Species

Homo sapiens

Ensembl Gene

ENSG00000159461

Encoded Proteins

IDBP-31787

autocrine motility factor receptor

IDBP-811456

autocrine motility factor receptor, E3 ubiquitin protein ligase

IDBP-745189

IDBP-752475

IDBP-748912

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25526307

Upon cytoplasmic DNA stimulation, the endoplasmic reticulum protein AMFR is recruited to and interacts with TMEM173 in an INSIG1-dependent manner.

Entrez Gene

Summary

This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:56361452-56425538

Strand

Reverse strand

Band

q13

Transcripts

ENST00000290649	ENSP00000290649
ENST00000492830	ENSP00000473636
ENST00000566334
ENST00000567738	ENSP00000456288
ENST00000568325
ENST00000568657
ENST00000564283
ENST00000565445	ENSP00000456745
ENST00000568762
ENST00000566757
ENST00000563285
ENST00000563664	ENSP00000455842

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	116 [view]
Protein-Protein	115 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006928	cellular component movement
GO:0007165	signal transduction
GO:0007568	aging
GO:0007611	learning or memory
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0045087	innate immune response (InnateDB)
GO:0051259	protein oligomerization

Cellular Component

GO:0000836	Hrd1p ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031751

View Gene Order

ENSBTAG00000003798

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.295137 Hs.593157

RefSeq

NM_001144 XM_005255889

HUGO

OMIM

CCDS

CCDS10758

HPRD

09130

IMGT

EMBL

GenPept

RNA Seq Atlas