Version 5.4
Homo sapiens Gene: WDR35
Summary
InnateDB Gene IDBG-31861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR35
Gene Name WD repeat domain 35
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118965
Encoded Proteins
IDBP-31867
WD repeat domain 35
IDBP-31869
WD repeat domain 35
IDBP-365243
WD repeat domain 35
IDBP-365249
WD repeat domain 35
IDBP-365252
WD repeat domain 35
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:19910260-19990131
Strand Reverse strand
Band p24.1
Transcripts
ENST00000345530 ENSP00000314444
ENST00000281405 ENSP00000281405
ENST00000445063 ENSP00000390105
ENST00000414212 ENSP00000390802
ENST00000453014 ENSP00000404409
ENST00000494964
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0035721 intraciliary retrograde transport
GO:0042384 cilium assembly
Cellular Component
GO:0005813 centrosome
GO:0005930 axoneme
GO:0030991 intraciliary transport particle A
GO:0036064 ciliary basal body
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000066643
View Gene Order
Pathways
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.205427 Hs.712670
RefSeq NM_001006657 NM_020779
HUGO
OMIM
CCDS CCDS1695 CCDS33152
HPRD 15667
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca