InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMAD7

Summary

InnateDB Gene

IDBG-3195.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAD7

Gene Name

SMAD family member 7

Synonyms

CRCS3; MADH7; MADH8

Species

Homo sapiens

Ensembl Gene

ENSG00000101665

Encoded Proteins

IDBP-3197

SMAD family member 7

IDBP-727061

IDBP-728027

IDBP-725745

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 12589052

Inhibitory SMAD7, a direct target gene for transforming growth factor-beta (TGF-beta), mediates TGF-beta1-induced apoptosis in several cell types and acts as a scaffolding protein to facilitate TAK1- and MKK3-mediated activation of p38.

PMID 20171181

SMAD7 acts as a critical mediator for effective TGF-beta1-mediated suppression of IL-1R/TLR signalling, by simultaneous binding to discrete regions of Pellino-1.

Entrez Gene

Summary

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:48919853-48950711

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000262158	ENSP00000262158
ENST00000545051
ENST00000591805	ENSP00000466902
ENST00000586093	ENSP00000465590
ENST00000585986
ENST00000588190
ENST00000589634	ENSP00000467621
ENST00000587336

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	144 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	8 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008013	beta-catenin binding
GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031625	ubiquitin protein ligase binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0048185	activin binding
GO:0070411	I-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001657	ureteric bud development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0022409	positive regulation of cell-cell adhesion
GO:0030336	negative regulation of cell migration
GO:0030509	BMP signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0031397	negative regulation of protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925	regulation of activin receptor signaling pathway
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0034333	adherens junction assembly
GO:0034616	response to laminar fluid shear stress
GO:0034629	cellular protein complex localization
GO:0035556	intracellular signal transduction
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048844	artery morphogenesis
GO:0050821	protein stabilization
GO:0051444	negative regulation of ubiquitin-protein transferase activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0055117	regulation of cardiac muscle contraction
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060412	ventricular septum morphogenesis
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0016342	catenin complex
GO:0043234	protein complex