Version 5.4
Homo sapiens Gene: NCOR1
Summary
InnateDB Gene IDBG-31971.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCOR1
Gene Name nuclear receptor corepressor 1
Synonyms hN-CoR; N-CoR; N-CoR1; PPP1R109; TRAC1
Species Homo sapiens
Ensembl Gene ENSG00000141027
Encoded Proteins
IDBP-31973
nuclear receptor corepressor 1
IDBP-238645
nuclear receptor corepressor 1
IDBP-238647
nuclear receptor corepressor 1
IDBP-238649
nuclear receptor corepressor 1
IDBP-238651
nuclear receptor corepressor 1
IDBP-370220
nuclear receptor corepressor 1
IDBP-370238
nuclear receptor corepressor 1
IDBP-370250
nuclear receptor corepressor 1
IDBP-370251
nuclear receptor corepressor 1
IDBP-761087
IDBP-761371
IDBP-761107
IDBP-764477
IDBP-762991
IDBP-810207
nuclear receptor corepressor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:16029157-16218185
Strand Reverse strand
Band p11.2
Transcripts
ENST00000268712 ENSP00000268712
ENST00000395857 ENSP00000379198
ENST00000395851 ENSP00000379192
ENST00000395849 ENSP00000379190
ENST00000395848 ENSP00000379189
ENST00000458113
ENST00000436068 ENSP00000389839
ENST00000411510 ENSP00000407998
ENST00000436828 ENSP00000387727
ENST00000430577 ENSP00000410784
ENST00000470782
ENST00000464381
ENST00000472189
ENST00000460276 ENSP00000462794
ENST00000466825
ENST00000582565
ENST00000579606 ENSP00000462281
ENST00000579974
ENST00000579573 ENSP00000461959
ENST00000580617
ENST00000583234
ENST00000583226
ENST00000580554 ENSP00000463169
ENST00000582357 ENSP00000462308
ENST00000585296
ENST00000584872
ENST00000603989 ENSP00000474008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 236 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 236 [view]
Protein-Protein 223 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0035033 histone deacetylase regulator activity
GO:0035257 nuclear hormone receptor binding
GO:0042826 histone deacetylase binding
GO:0042974 retinoic acid receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046965 retinoid X receptor binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0010467 gene expression
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016568 chromatin modification
GO:0021794 thalamus development
GO:0031065 positive regulation of histone deacetylation
GO:0032922 circadian regulation of gene expression
GO:0040014 regulation of multicellular organism growth
GO:0042632 cholesterol homeostasis
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046329 negative regulation of JNK cascade
GO:0051225 spindle assembly
GO:0060318 definitive erythrocyte differentiation
GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:2000191 regulation of fatty acid transport
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
GO:0016020 membrane
GO:0016580 Sin3 complex
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018501
View Gene Order
ENSBTAG00000013271
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_3
Notch pathway
REACTOME
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_172623
Chromatin organization pathway
REACT_299
Signaling by NOTCH pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_111217
Metabolism pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
erbb4_pathway
ErbB4 signaling events
hdac_classi_pathway
Signaling events mediated by HDAC Class I
cmyb_pathway
C-MYB transcription factor network
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.462323 Hs.604301 Hs.609364 Hs.657442 Hs.666008
RefSeq NM_001190438 NM_001190440 NM_006311 XM_006721604
HUGO
OMIM
CCDS CCDS11175 CCDS54094 CCDS54095
HPRD 02911
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca