Version 5.4
Homo sapiens Gene: NFKB1
Summary
InnateDB Gene IDBG-31974.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFKB1
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Synonyms EBP-1; KBF1; NF-kappa-B; NF-kappaB; NF-kB1; NFkappaB; NFKB-p105; NFKB-p50; p105; p50
Species Homo sapiens
Ensembl Gene ENSG00000109320
Encoded Proteins
IDBP-31976
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
IDBP-240803
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
IDBP-477358
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
IDBP-481194
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
IDBP-481312
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
IDBP-480266
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
IDBP-483959
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
IDBP-713144
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 14593105
NFKB1 (p50) is a distinct form of NF-kappaB that interacts with STAT3 and cooperates with STAT3 bound to GAS sites.
PMID 8152812
NFKB1 is a subunit of the NF-kappaB transcriptional regulator complex. NF-kappaB is an inducible transcription factor that regulates the expression of numerous genes involved in immune and inflammation responses and in cellular growth control.
PMID 21343618
NFKB1 enforces specificity of cellular response to pathogens by binding to a subset of IRE sequences in IFN-inducible genes. NFKB1 deficiency results in the inappropriate production of IFNB in response to bacterial DNA sensed by TLR9. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21343618
[Mus musculus] Nfkb1 enforces specificity of cellular response to pathogens by binding to a subset of IRE sequences in IFN-inducible genes. Nfkb1 deficiency results in the inappropriate production of Ifnb in response to bacterial DNA sensed by Tlr9.
PMID 24270517
[Mus musculus] Mir126-Kdr axis is an important regulator of the innate response. Mir126 controls the survival and function of plasmacytoid dendritic cells and regulates gene expression of Tlr7, Tlr9, Nfkb1 and Kdr.
PMID 25367573
[Mus musculus] Ripk3 has a novel function in NF-kB activation, dendritic cell biology, innate inflammatory-cytokine expression, and injury-induced tissue repair.
Entrez Gene
Summary This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:102501329-102617302
Strand Forward strand
Band q24
Transcripts
ENST00000226574 ENSP00000226574
ENST00000394820 ENSP00000378297
ENST00000511926 ENSP00000420904
ENST00000507079 ENSP00000426147
ENST00000505458 ENSP00000424790
ENST00000509165 ENSP00000423877
ENST00000513803
ENST00000502367
ENST00000510638
ENST00000508584 ENSP00000424815
ENST00000504044
ENST00000600343 ENSP00000469340
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 322 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated
Total 322 [view]
Protein-Protein 228 [view]
Protein-DNA 94 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0001071 nucleic acid binding transcription factor activity
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0031072 heat shock protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001818 negative regulation of cytokine production
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0007165 signal transduction
GO:0009617 response to bacterium
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010884 positive regulation of lipid storage
GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
GO:0010957 negative regulation of vitamin D biosynthetic process
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032375 negative regulation of cholesterol transport
GO:0032481 positive regulation of type I interferon production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0045083 negative regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046688 response to copper ion
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071316 cellular response to nicotine
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071375 cellular response to peptide hormone stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:2000630 positive regulation of miRNA metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0033256 I-kappaB/NF-kappaB complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028163
View Gene Order
ENSBTAG00000020270
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_24
TSLP pathway
NetPath_26
TWEAK pathway
NetPath_56
Prolactin pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_118563
RIP-mediated NFkB activation via ZBP1 pathway
REACT_118764
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_24969
TRAF6 mediated NF-kB activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_12555
Downstream TCR signaling pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_23950
Interleukin-1 processing pathway
REACT_118656
Activation of NF-kappaB in B cells pathway
REACT_13443
Regulated proteolysis of p75NTR pathway
REACT_13696
NF-kB is activated and signals survival pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_12526
TCR signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_13537
p75NTR signals via NF-kB pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_163773
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_22232
Signaling by Interleukins pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa05222
Small cell lung cancer pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05212
Pancreatic cancer pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
hsa05140
Leishmaniasis pathway
hsa05146
Amoebiasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
B cell receptor signaling pathway
INOH website
TNFR1 signaling pathway pathway
PID NCI
cd40_pathway
CD40/CD40L signaling
nfkappabatypicalpathway
Atypical NF-kappaB pathway
ceramide_pathway
Ceramide signaling pathway
lysophospholipid_pathway
LPA receptor mediated events
il1pathway
IL1-mediated signaling events
tnfpathway
TNF receptor signaling pathway
il12_2pathway
IL12-mediated signaling events
hdac_classi_pathway
Signaling events mediated by HDAC Class I
epopathway
EPO signaling pathway
reg_gr_pathway
Glucocorticoid receptor regulatory network
bcr_5pathway
BCR signaling pathway
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
il23pathway
IL23-mediated signaling events
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
il2_pi3kpathway
IL2 signaling events mediated by PI3K
nfkappabalternativepathway
Alternative NF-kappaB pathway
amb2_neutrophils_pathway
amb2 Integrin signaling
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
telomerasepathway
Regulation of Telomerase
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.618430
RefSeq NM_001165412 NM_003998 XM_005263029 XM_006714229
HUGO
OMIM
CCDS CCDS3657 CCDS54783
HPRD 01238
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca