Homo sapiens Gene: EIF4G2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-31984.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | EIF4G2 | ||||||||||||||||||||||
Gene Name | eukaryotic translation initiation factor 4 gamma, 2 | ||||||||||||||||||||||
Synonyms | AAG1; DAP5; NAT1; P97 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000110321 | ||||||||||||||||||||||
Encoded Proteins |
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
eukaryotic translation initiation factor 4 gamma, 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 11:10797050-10809110 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | p15.4 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
ISG15 antiviral mechanism pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
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KEGG |
Viral myocarditis pathway
RNA transport pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.183684 | ||||||||||||||||||||||
RefSeq | NM_001042559 NM_001172705 NM_001418 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS31428 CCDS41618 | ||||||||||||||||||||||
HPRD | 09084 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||