InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RB1

Summary

InnateDB Gene

IDBG-32092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RB1

Gene Name

retinoblastoma 1

Synonyms

OSRC; p105-Rb; pp110; PPP1R130; pRb; RB

Species

Homo sapiens

Ensembl Gene

ENSG00000139687

Encoded Proteins

IDBP-32094

retinoblastoma 1

IDBP-590397

retinoblastoma 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22310660

RB1 positively regulates TLR3 expression by modulating the transcription factor E2F1. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22310660

[Mus musculus] Rb1 positively regulates Tlr3 expression by modulating the transcription factor E2f1.

Entrez Gene

Summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:48303751-48481986

Strand

Forward strand

Band

q14.2

Transcripts

ENST00000267163	ENSP00000267163
ENST00000467505	ENSP00000434702
ENST00000480491
ENST00000484879
ENST00000525036
ENST00000531171

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 479 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	479 [view]
Protein-Protein	427 [view]
Protein-DNA	47 [view]
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0019900	kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0050681	androgen receptor binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000075	cell cycle checkpoint
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006469	negative regulation of protein kinase activity
GO:0007050	cell cycle arrest
GO:0007070	negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0007093	mitotic cell cycle checkpoint
GO:0007265	Ras protein signal transduction
GO:0007346	regulation of mitotic cell cycle
GO:0008150	biological_process
GO:0008285	negative regulation of cell proliferation
GO:0016032	viral process
GO:0030182	neuron differentiation
GO:0030521	androgen receptor signaling pathway
GO:0031134	sister chromatid biorientation
GO:0031175	neuron projection development
GO:0034088	maintenance of mitotic sister chromatid cohesion
GO:0034349	glial cell apoptotic process
GO:0035914	skeletal muscle cell differentiation
GO:0042551	neuron maturation
GO:0043353	enucleate erythrocyte differentiation
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043550	regulation of lipid kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045445	myoblast differentiation
GO:0045651	positive regulation of macrophage differentiation
GO:0045786	negative regulation of cell cycle
GO:0045842	positive regulation of mitotic metaphase/anaphase transition
GO:0045879	negative regulation of smoothened signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051146	striated muscle cell differentiation
GO:0051301	cell division
GO:0051402	neuron apoptotic process
GO:0051726	regulation of cell cycle
GO:0071459	protein localization to chromosome, centromeric region
GO:0071922	regulation of cohesin localization to chromatin
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0090230	regulation of centromere complex assembly
GO:0097284	hepatocyte apoptotic process
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0000785	chromatin
GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005819	spindle
GO:0016514	SWI/SNF complex
GO:0016605	PML body
GO:0035189	Rb-E2F complex