Version 5.4
Homo sapiens Gene: AQP6
Summary
InnateDB Gene IDBG-32170.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AQP6
Gene Name aquaporin 6, kidney specific
Synonyms AQP2L; KID
Species Homo sapiens
Ensembl Gene ENSG00000086159
Encoded Proteins
IDBP-32174
aquaporin 6, kidney specific
IDBP-584821
aquaporin 6, kidney specific
IDBP-809255
aquaporin 6, kidney specific
IDBP-809256
aquaporin 6, kidney specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:49967194-49977139
Strand Forward strand
Band q13.12
Transcripts
ENST00000315520 ENSP00000320247
ENST00000489786
ENST00000551733 ENSP00000449830
ENST00000615425 ENSP00000477688
ENST00000618286 ENSP00000477759
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005253 anion channel activity
GO:0015112 nitrate transmembrane transporter activity
GO:0015250 water channel activity
Biological Process
GO:0006810 transport
GO:0006833 water transport
GO:0007588 excretion
GO:0015706 nitrate transport
GO:0042476 odontogenesis
GO:0055085 transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030658 transport vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043144
View Gene Order
ENSBTAG00000012782
Not yet available
Pathways
NETPATH
REACTOME
REACT_23826
Passive transport by Aquaporins pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23887
Aquaporin-mediated transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001652
HUGO
OMIM
CCDS CCDS31798
HPRD 03226
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca