Version 5.4
Homo sapiens Gene: RACGAP1
Summary
InnateDB Gene IDBG-32209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RACGAP1
Gene Name Rac GTPase activating protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161800
Encoded Proteins
IDBP-32211
Rac GTPase activating protein 1
IDBP-374726
Rac GTPase activating protein 1
IDBP-374730
Rac GTPase activating protein 1
IDBP-591657
Rac GTPase activating protein 1
IDBP-595220
Rac GTPase activating protein 1
IDBP-592246
Rac GTPase activating protein 1
IDBP-602416
Rac GTPase activating protein 1
IDBP-594963
Rac GTPase activating protein 1
IDBP-596054
Rac GTPase activating protein 1
IDBP-583665
Rac GTPase activating protein 1
IDBP-602466
Rac GTPase activating protein 1
IDBP-584899
Rac GTPase activating protein 1
IDBP-587373
Rac GTPase activating protein 1
IDBP-594806
Rac GTPase activating protein 1
IDBP-583774
Rac GTPase activating protein 1
IDBP-599201
Rac GTPase activating protein 1
IDBP-601299
Rac GTPase activating protein 1
IDBP-592321
Rac GTPase activating protein 1
IDBP-597815
Rac GTPase activating protein 1
IDBP-599019
Rac GTPase activating protein 1
IDBP-583571
Rac GTPase activating protein 1
IDBP-596964
Rac GTPase activating protein 1
IDBP-585925
Rac GTPase activating protein 1
IDBP-600314
Rac GTPase activating protein 1
IDBP-595797
Rac GTPase activating protein 1
IDBP-588277
Rac GTPase activating protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:49976923-50033136
Strand Reverse strand
Band q13.12
Transcripts
ENST00000312377 ENSP00000309871
ENST00000427314 ENSP00000404190
ENST00000454520 ENSP00000404808
ENST00000548961 ENSP00000446889
ENST00000551016 ENSP00000449374
ENST00000547905 ENSP00000449370
ENST00000549342 ENSP00000449565
ENST00000547061
ENST00000548320 ENSP00000448507
ENST00000548598 ENSP00000449574
ENST00000552310 ENSP00000448697
ENST00000548158
ENST00000550149 ENSP00000446642
ENST00000546786 ENSP00000447429
ENST00000546595 ENSP00000449963
ENST00000551145 ENSP00000450064
ENST00000548824 ENSP00000449170
ENST00000551260 ENSP00000448860
ENST00000548644 ENSP00000449620
ENST00000546723 ENSP00000449669
ENST00000552921 ENSP00000447393
ENST00000552157 ENSP00000448968
ENST00000548247 ENSP00000450074
ENST00000546764 ENSP00000447177
ENST00000551876 ENSP00000449186
ENST00000549777 ENSP00000448707
ENST00000550651 ENSP00000449959
ENST00000552004 ENSP00000448136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008017 microtubule binding
GO:0019901 protein kinase binding
GO:0043014 alpha-tubulin binding
GO:0043015 gamma-tubulin binding
GO:0046872 metal ion binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0000915 cytokinesis, actomyosin contractile ring assembly
GO:0007018 microtubule-based movement
GO:0007108 cytokinesis, initiation of separation
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007283 spermatogenesis
GO:0007405 neuroblast proliferation
GO:0007596 blood coagulation
GO:0008272 sulfate transport
GO:0009790 embryo development
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032467 positive regulation of cytokinesis
GO:0035556 intracellular signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051256 spindle midzone assembly involved in mitosis
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0030496 midbody
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032154 cleavage furrow
GO:0051233 spindle midzone
GO:0070062 extracellular vesicular exosome
GO:0072686 mitotic spindle
GO:0097149 centralspindlin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023015
View Gene Order
ENSBTAG00000012784
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
rac1_pathway
RAC1 signaling pathway
cdc42_reg_pathway
Regulation of CDC42 activity
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.505469 Hs.618868 Hs.650500
RefSeq NM_001126103 NM_001126104 NM_013277 XM_005268811 XM_005268812 XM_005268813 XM_005268814 XM_005268815 XM_005268816 XM_006719359 XM_006719360
HUGO
OMIM
CCDS CCDS8795
HPRD 05402
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca