Homo sapiens Gene: DKK3
Summary
InnateDB Gene IDBG-32224.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DKK3
Gene Name dickkopf 3 homolog (Xenopus laevis)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000050165
Encoded Proteins
dickkopf homolog 3 (Xenopus laevis)
dickkopf homolog 3 (Xenopus laevis)
dickkopf homolog 3 (Xenopus laevis)
dickkopf homolog 3 (Xenopus laevis)
dickkopf homolog 3 (Xenopus laevis)
dickkopf homolog 3 (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:11963106-12009769
Strand Reverse strand
Band p15.3
Transcripts
ENST00000326932 ENSP00000314910
ENST00000396505 ENSP00000379762
ENST00000527132
ENST00000525493 ENSP00000433112
ENST00000528188
ENST00000532372
ENST00000525927
ENST00000532873
ENST00000533813 ENSP00000435269
ENST00000534511 ENSP00000436645
ENST00000529338 ENSP00000431604
ENST00000526218
ENST00000531309
ENST00000530694
ENST00000534479
ENST00000533900
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007275 multicellular organismal development
GO:0009653 anatomical structure morphogenesis
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030325 adrenal gland development
GO:0032348 negative regulation of aldosterone biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000065 negative regulation of cortisol biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
Wnt signaling pathway pathway
PID NCI
Cross-References
SwissProt Q9UBP4
TrEMBL E9PHY3 E9PKK9 E9PKW6 F6SYF8
UniProt Splice Variant
Entrez Gene 27122
UniGene Hs.292156
RefSeq NM_001018057 NM_013253 NM_015881 XM_006718177 XM_006718178
HUGO HGNC:2893
OMIM 605416
CCDS CCDS7808
HPRD
IMGT
EMBL AB033421 AB034203 AB035182 AB057591 AB057804 AC124276 AF177396 AK289897 AY358378 BC007660 CH471064
GenPept AAF02676 AAH07660 AAQ88744 BAA85488 BAA87044 BAA90548 BAB84360 BAB84361 BAF82586 EAW68534 EAW68535 EAW68537
RNA Seq Atlas 27122