Version 5.4
Homo sapiens Gene: ANGPT1
Summary
InnateDB Gene IDBG-32292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANGPT1
Gene Name angiopoietin 1
Synonyms AGP1; AGPT; ANG1
Species Homo sapiens
Ensembl Gene ENSG00000154188
Encoded Proteins
IDBP-32294
angiopoietin 1
IDBP-481470
angiopoietin 1
IDBP-474933
angiopoietin 1
IDBP-482868
angiopoietin 1
IDBP-477060
angiopoietin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22015631
ANGPT1 promotes IL8 synthesis and release in neutrophils.
InnateDB Annotation from Orthologs
Summary
PMID 22015631
[Mus musculus] Angpt1 promotes IL8 synthesis and release in neutrophils. (Demonstrated in human)
Entrez Gene
Summary Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:107249482-107498055
Strand Reverse strand
Band q23.1
Transcripts
ENST00000297450 ENSP00000297450
ENST00000517746 ENSP00000428340
ENST00000520734 ENSP00000430750
ENST00000520052 ENSP00000429349
ENST00000518386
ENST00000521950
ENST00000522400
ENST00000520033 ENSP00000428908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0002040 sprouting angiogenesis
GO:0002092 positive regulation of receptor internalization
GO:0007162 negative regulation of cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007596 blood coagulation
GO:0010595 positive regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014842 regulation of satellite cell proliferation
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030210 heparin biosynthetic process
GO:0031398 positive regulation of protein ubiquitination
GO:0031589 cell-substrate adhesion
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034394 protein localization to cell surface
GO:0043066 negative regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0045785 positive regulation of cell adhesion
GO:0048014 Tie signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0050918 positive chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072012 glomerulus vasculature development
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022309
View Gene Order
ENSBTAG00000014051
Not yet available
Pathways
NETPATH
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
shp2_pathway
SHP2 signaling
Cross-References
SwissProt
TrEMBL E5RFF4
UniProt Splice Variant
Entrez Gene 284
UniGene Hs.369675 Hs.613780
RefSeq NM_001146 NM_001199859
HUGO HGNC:484
OMIM 601667
CCDS CCDS56551 CCDS6306
HPRD 03392
IMGT
EMBL AC091010 AP000428 AP003480
GenPept
RNA Seq Atlas 284

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca