InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VCAN

Summary

InnateDB Gene

IDBG-32298.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VCAN

Gene Name

versican

Synonyms

CSPG2; ERVR; GHAP; PG-M; WGN; WGN1

Species

Homo sapiens

Ensembl Gene

ENSG00000038427

Encoded Proteins

IDBP-32300

versican

IDBP-32302

versican

IDBP-32304

versican

IDBP-483383

versican

IDBP-477147

versican

IDBP-477632

versican

IDBP-485211

versican

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:83471465-83582303

Strand

Forward strand

Band

q14.2

Transcripts

ENST00000265077	ENSP00000265077
ENST00000343200	ENSP00000340062
ENST00000342785	ENSP00000342768
ENST00000503923
ENST00000512590	ENSP00000425959
ENST00000513960	ENSP00000426251
ENST00000513984	ENSP00000426715
ENST00000502527	ENSP00000421362
ENST00000515397
ENST00000513016
ENST00000507162
ENST00000505615

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding
GO:0005540	hyaluronic acid binding
GO:0030246	carbohydrate binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0005975	carbohydrate metabolic process
GO:0007155	cell adhesion
GO:0007275	multicellular organismal development
GO:0007507	heart development
GO:0008037	cell recognition
GO:0008347	glial cell migration
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0043202	lysosomal lumen
GO:0043231	intracellular membrane-bounded organelle