InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHSY1

Summary

InnateDB Gene

IDBG-32338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHSY1

Gene Name

chondroitin sulfate synthase 1

Synonyms

CHSY; ChSy-1; CSS1; TPBS

Species

Homo sapiens

Ensembl Gene

ENSG00000131873

Encoded Proteins

IDBP-32340

chondroitin sulfate synthase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:101175723-101251932

Strand

Reverse strand

Band

q26.3

Transcripts

ENST00000254190	ENSP00000254190
ENST00000543813
ENST00000560766
ENST00000561414
ENST00000561143
ENST00000559384

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008376	acetylgalactosaminyltransferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0046872	metal ion binding
GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030279	negative regulation of ossification
GO:0031667	response to nutrient levels
GO:0044281	small molecule metabolic process